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Inhalation grade particles
Hovione is a global expert in particle engineering, an essential technology when developing inhalation drug products.
Inhalation grade particle generation strategies
Within inhalation drug development services, Hovione focuses on the development of enabling particle engineering solutions for inhalation drug development, while maintaining tight control over conventional development techniques.
Hovione has developed its own toolkit to address the requirements of a new generation of inhalation grade particles, including bottom-up approaches such as controlled microcrystallization and top-down approaches, such as air jet milling, spray drying and wet polishing.
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Bottom-up approach Controlled crystallization |
Top-down approach Air jet milling Spray drying Wet polishing |
|
|---|---|---|
| Strengths | • Target PS in a single step | • Control over PS and distribution • Tailoring morphology and surface properties • Scalable approaches available |
| Limitations | • Process and scale-up complexity • Wide PS distribution, agglomeration • Limited morphology tuning |
• Requires isolation step for wet methods • Challenges for thermolabile molecules |
Scale-up & QbD approaches for spray-dried inhalation formulations
describe the strong position of inhalable products in preclinical and clinical pipelines.
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