HPAPI – Highly Potent API

Many of NCE are considered potent compounds, meaning occupational exposure limits (OEL) <10 µg/m³, which requires special handling conditions. Hovione has invested in its facilities in Loures, Cork and New Jersey to provide the necessary containment, defined individual protection equipment and also developed working practices to safely handle these compounds.  

Our service for HPAPIs covers both Drug Substance and Particle Engineering for compounds. Our multipurpose facilities can support Drug Substance services with an OEL down to 1 µg/m3.

In the case of spray drying services Hovione can handle compounds with an OEL down to 0.03 µg/m³.

This combination is unique in the industry and offers our customers the ability synthesize an HPAPI and then convert seamlessly to a spray dried dispersion all on the same site.