Catalytic hydrogenation is a versatile technology applicable to numerous synthetic transformations. As a consequence, hydrogenation is routinely encountered in drug substance synthesis.
Hovione has vast experience in developing hydrogenation processes using both heterogeneous and homogeneous catalysis and operates this technology up to large commercial scale (100’s MT per annum). Our development team has a wide range of laboratory scale hydrogenators available (100 mL to 7.5 L) for process development purposes. For subsequent scale up we have extensive pilot and large scale hydrogenation capacity with broad geographic coverage. A summary of the pilot and commercial hydrogenation capabilities is provided below.
Please talk to us if your project would benefit from partnering with an organization with deep expertise in scaling hydrogenations.
|Site||Reactor capacity||Pressure Rating||Material of Construction|
|Loures||100 L||100 bar||Hastelloy|
|2000 L||25 bar||Stainless steel|
|3000 L||10 bar||Hastelloy|
|3000 L||10 bar||Stainless stell - 904L|
|5000 L||25 bar||Hastelloy|
|Macau||600 L||20 bar||Stainless steel|
|3000 L||10 bar||Stainless steel|
|Cork||2500 L||6 bar||Glass lined|
|6000 L||12 bar||Stainless steel|