Press Room

DDL 2021

Start
Wednesday, December 08, 2021 - 00:00
End
Friday, December 10, 2021 - 00:00
Location: Online

 

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Hovione's Scientists On-Demand Presentations:

 

Hovione scientist at DDL Conference Nasal PAMPA intranasal drug permeability | Hovione

 

Nasal-PAMPA: a novel in vitro tool for prediction of intranasal drug permeability

Presenter: Patrícia Henriques, PhD Student, R&D DPD 

 

Abstract:

In nasal drug product development, biorelevant in vitro methodologies are vital in order to select promising compounds or formulations, potentially reducing pre-clinical and clinical trials. Permeability assays are often applied to predict drug absorption and bioavailability. For nasal delivery products, permeation models include ex vivo models using excised nasal mucosa and in vitro cell culture models. However, ex vivo models present high variability and cell culture models are very time consuming. The Parallel Artificial Membrane Permeability Assay (PAMPA) has emerged as a high throughput screening tool to evaluate drug permeability, and it has been applied to several barriers such as the intestine, skin or blood-brain-barrier. Herein, a new PAMPA model was developed and optimized to predict nasal permeability, using a biorelevant donor medium containing mucin. The apparent permeability (Papp) of 15 reference compounds was assessed in six different experimental conditions. The model with 0.5% (w/v) mucin in the donor compartment and 2% (w/v) phosphatidylcholine in the lipid membrane correctly distinguished high and low permeable compounds, with no false positives or negatives. In addition, it exhibited the highest correlation with permeation across human nasal epithelial RPMI 2650 cells (R2 = 0.71). Overall, the optimized PAMPA model was reproducible, predictive and inexpensive, showing to be a promising non-cell based and biorelevant in vitro tool that could be applied in an early screening stages of new nasal drug delivery products.

Hovione scientist at DDL Conference DPI formulation screening: particle-particle interaction | Hovione
Hovione scientist Joao Pereira at DDL Conference DPI formulation screening: particle-particle interaction | Hovione

 

Leveraging DPI formulation screening: particle-particle interaction

Presenters:

Raquel Borda D’Água, Associate Analytical Scientist, R&D Analytical Development

João Pereira, Manager R&D Analytical Development

 

Abstract:

Dry powder inhalers (DPIs) have attracted enormous attention worldwide due to its local targeting, rapid drug effect and reduced systemic toxicity. However, DPI formulations consist of highly cohesive powders that tend to agglomerate. Therefore, understanding the role of cohesive-adhesive forces in different formulations and establishing a predictive approach for aerodynamic particle size distribution (aPSD) is thus, highly beneficial. The purpose of this study is to explore the relationship between powder dispersibility with the aerodynamic performance of different DPI formulations. Sympatec was used to characterise powder dispersibility and inherent cohesion and adhesion forces at different pressures. Powder dispersibility obtained by Sympatec and aerodynamic properties from the NGI analysis were evaluated in order to deeper understand the characteristic behaviour of these formulations

 

 





 

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Inhalation high performance APIs particle engineering formulation DPIs pdf | Hovione

 





 



 

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With key expansions coming to fruition on either side of the pond, specialist CDMO Hovione is making sure that drugmakers can access its particle engineering expertise across multiple geographies.  That flexibility will be key for the Portugal-based company in the coming years as the pharmaceutical industry continues to embrace more regional supply chains. In a recent interview, Hovione's David Basile, VP of technical operations for the Americas, discussed this trend and the manufacturer's expansion project, which is set to come online in New Jersey next month.  In the coming weeks, Hovione plans to debut a new spray drying expansion at its campus in East Windsor, New Jersey. The company has invested $100 million to expand its campus, including new construction and the acquisition of an additional facility and greenfield land.  Specifically, one of two pharmaceutical spray drying-3 units, or PSD-3 units, will come online in the coming weeks to tackle amorphous active pharmaceutical ingredients (APIs) and amorphous solid dispersions, according to the company. With some 80% of new small molecules in development insoluble in water, Hovione’s particle engineering and amorphous solid dispersion platform helps medicine developers improve the solubility, bioavailability, and, in some cases, the stability of their drug candidates, Basile said.  The company boasts spray dryers from the lab scale to PSD3 at its original facility in East Windsor, in addition to the pair of large-scale machines about to be activated at the campus' new facility.  “We’re going for a single, unified site with capabilities across the campus to do drug substance through finished drug product under one governance and quality system,” - Basile told Fierce.   Read the full article at FiercePharma.com

Article

As expansions come online, CDMO Hovione aims to meet industry's 'dual supply and sourcing' zeal: exec

Mar 26, 2026