Press Room

AAPS 2024 PharmSci 360

Start
Sunday, October 20, 2024
End
Wednesday, October 23, 2024
Location: Salt Lake City, United States
Booth Number: 1939
Hovione is present at AAPS in October 2024, know more about the event and contact us to schedule a meeting

Visit Hovione’s booth at AAPS PharmSci 360 next October 20-23 in Salt Lake City and meet our team of experts.

The AAPS PharmSci 360 Annual Meeting is organized by the American Association of Pharmaceutical Scientists (AAPS). The event provides a platform for pharmaceutical scientists from academia, industry, government, and other institutions worldwide to exchange knowledge and discuss the latest advancements in the field.

Don't miss our experts' presentations in Salt Lake City

Oral Presentation, 155 F

Development of Spray Drying Processes Grounded on Innovative Approaches
Monday, October 21 | 10:30 AM – 11:00 AM
Presenting Author: Clara Sa Couto, Ph.D.

Short description: New BCS Class 2 drugs represent up to 70% of the pharmaceutical pipeline. Limited aqueous solubility has been one of the major hurdles in the development of oral-dosage forms, as poor solubility hinders oral bioavailability. Different formulation strategies and enabling technologies have been used to overcome low aqueous solubility, including complexation with other compounds, nano-milling and amorphous solid dispersions (ASD).
ASDs have emerged has one of the preferred methods to improve solubility, with industrially demonstrated processes and multiple approved treatments. Generally, the ASDs manufacturing methods are classified into solvent-based – spray drying (SD), electrospraying, rotary evaporation – and melting or fusion – hot-melt extrusion, KinetiSol, Three-dimensional (3D) printing.

The selection of the most suitable method depends on the nature of the API and the SD has been unanimously recognized as the leading technology due to not only the mild processing conditions but also due to scalability, commercial scale representative ASD material can be produced in laboratorial scale and kept across scales. (full description)

Key learnings:

  • Develop a robust process at lab scale and assure a successful scale-up
  • Understand how to use of mathematical models, rheological and analytical characterization, and PAT tools to improve SD process development
  • Understand how to use a Model Based Methodology to Establish the Design Space and a Commercial Process

Rapid Fire Presentation, 155 E

Streamlining Loss-in-Weight Feeding Process Development Using Predictive Tools
Monday, October 21 | 3:30 PM – 4:30 PM
Presenting Author: João Henriques, M.Sc.

Short description: Continuous Direct Compression (CDC) has gained increased attention due to its advantages over batch processing. In CDC, each material is individually fed into the system at a predefined rate via loss-in-weight feeders, making it essential to understand their behavior during processing. This study aimed to predict the feeding performance and ideal setup for a new material, based on material properties. This was achieved by correlating material properties and feeder setup with feeding performance. A wide range of materials, including excipients, APIs, and spray-dried excipients, were physically and rheologically characterized, and their feeding performance evaluated. Results indicate that feeding performance is predominantly influenced by variables related to density, cohesion, and flowability, which can be obtained by performing three characterization analyses. In turn, these properties determine how different setup options influence feeding behavior. This workflow allows a data-driven approach, significantly reducing the time and material spent on process development.

Key learning: In this presentation, attendees will explore the potential of using predictive strategies to develop and optimize a loss-in-weight feeding process for continuous tableting using minimum analytical and rheological characterization.

 

Join Hovione at our poster presentations

Dispersome® as an Advanced Platform for Oral Bioenhancement

Monday, October 21 | 12:30 PM – 1:30 PM
Authors: Ana Filipa Ferreira Ph.D., Liliana Rodrigues Ph.D., Carolina Pinheiro Ph.D., Maria Paisana Ph.D., Emmanuel Heinrich Ph.D., Ines Ramos Ph.D., Sara Pinto M.Sc.
Presenting Author: João Henriques, M.Sc.

Improving Lipid Nanoparticles Stability for mRNA Lung Delivery Through Nebulization

Tuesday, October 22 | 9:30 AM – 10:30 AM
Authors: Ricardo Miguel Velez M.Sc., Eunice Costa Ph.D., Susana Saldanha Ph.D., Rute Mota M.Sc., Luís Marques Ph.D.
Presenting Author: Eunice Costa Ph.D.

Natural-Based ASD Platforms: Enhancing Stability and Bioavailability

Tuesday, October 22 | 9:30 AM – 10:30 AM
Authors: Francisco Tavares M.Sc., Clara Sa Couto Ph.D., Joana Cotrim B.Sc., Ines Ramos Ph.D., Vanda Serra Ph.D., Maria Paisana Ph.D.
Presenting Author: Clara Sa Couto, Ph.D.

Protein Stabilization Sweet Spot: Novel Class of Sugar-Based Excipients Enabling Downstream Processing and Formulation

Tuesday, October 22 | 12:30 PM – 1:30 PM
Authors: Paulo Roque Lino, Eva C. Lourenço, Joana Diogo, Ricardo Gonçalves, Osvaldo S. Ascenso, Joana Cristóvão, Ana Filipa Ferreira, Luís Marques Ph.D.
Presenting Author: Eunice Costa Ph.D.

 

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Drug Substance at Hovione

Your partner in custom development and manufacturing of APIs.

The Leader in Spray Drying

Know how to overcome your solubility issues with the best scale-up science.

The Future is Continuous

Meet our experts and find out if Continuous Tableting is right for your product.

Industrialization of Innovative Platforms

Learn more about our Large-scale GMP-compliant platforms that support your project from development to commercialization. 

 

 

Also in the Press Room

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ViSync® Technologies, a joint venture between Hovione, a global specialist integrated CDMO and leader in spray drying and particle engineering, and iBET (Instituto de Biologia Experimental e Tecnológica), a not-for-profit R&D institution specializing in Biotechnology and Life Sciences, is proud to announce the appointment of Elsa Abranches as its Chief Scientific Officer (CSO). Headquartered in Oeiras, Portugal, ViSync® Technologies was established to address unmet technological needs in the pharmaceutical industry, focusing on developing innovative solutions for the cell and gene therapy space. By leveraging Hovione's expertise in pharmaceutical development, particle engineering, and industrialization, alongside iBET’s pioneering research in biotechnological sciences, ViSync® is uniquely equipped to drive innovation in targeted delivery and stabilization of next-generation therapies.  Dr. Elsa Abranches brings over two decades of experience in cell and gene therapy, with a strong track record of leading diverse teams in dynamic environments. In her new role as ViSync® CSO, she will drive the company’s R&D strategy and scientific vision, positioning ViSync® as a leader in innovation within the dynamic and rapidly advancing field of cell and gene therapy. “We are thrilled to welcome Elsa Abranches as Chief Scientific Officer of ViSync®,” said Dr. Christoph Bruecher, Chairman of the Board of ViSync® and VP Business Transformation at Hovione. “Her expertise and vision in the field of advanced therapeutics will be pivotal in driving ViSync’s mission to create transformative solutions that empower pharmaceutical companies and improve patient treatment outcomes.” Dr. Manuel Carrondo, Director of the Board of ViSync® and Vice President of iBET, added, “Elsa’s appointment underscores our commitment to establishing ViSync® as a leader in cell and gene therapy innovation. Her scientific leadership will be critical as we tackle some of the most pressing challenges in the field of new modalities drug delivery.” Elsa Abranches, new Chief Scientific Officer of ViSync®, said: “Having worked in different countries and industries, I’m thrilled to bring my experience back home to join ViSync®. This new venture represents an incredible opportunity to collaborate with local and international partners to drive innovation in advanced therapeutics and help shape the future of life-changing therapies”.     About Hovione Hovione is an international company with over 60 years of experience in pharmaceutical development and manufacturing operations. As a Contract Development and Manufacturing Organization (CDMO) it has a fully integrated offering of services for drug substances, drug product intermediates and drug products. The company has four FDA inspected sites in the USA, Portugal, Ireland and China and development laboratories in Lisbon, Portugal and New Jersey, USA. Hovione provides pharmaceutical customers services for the development and compliant manufacture of innovative drugs, including highly potent compounds, and customized product solutions across the entire drug life cycle. In the inhalation area, Hovione offers a complete range of services, from API, formulation development and manufacturing, capsule filling and devices. Hovione's culture is based on innovation, quality and dependability. Hovione is a member of Rx-360, EFCG and participates actively in industry quality improvement initiatives to lead new global industry standards.   About iBET iBET is a private non-profit institution devoted to biotechnology research, with 35 years of experience creating and transferring knowledge to the global biopharma and biotech sectors. iBET’s core expertise lies on the development of bioprocesses and analytical tools for Advanced Therapeutic Medicinal Products (ATMPs), including cell and gene therapies, vaccines, antibodies and other innovative therapeutic products. Leveraged by the emerging areas of Data Science and Translational Immunology, we offer bespoke R&D services from early-stage R&D to GMP manufacturing. iBET’s infrastructure comprises cutting-edge laboratories, a GMP certified Analytical Services Unit, and a Late-Stage R&D and Bioproduction Unit, covering upstream and downstream process development, bioanalytical tools for critical quality attribute monitoring, to scale-up and tech transfer. iBET also hosts satellite laboratories of major pharmaceutical companies and serves as an incubation platform for start-up/spin-off companies. iBET is driven by its innovative and agile culture of continuous improvement and a strong sense of ambition, ownership and commitment in developing and delivering the best solutions to our stakeholders.     

News

ViSync® Technologies appoints Elsa Abranches as Chief Scientific Officer

Dec 19, 2024

International pharmaceutical contract development and manufacturing organisation (CDMO) Hovione has today officially commissioned an expansion at its manufacturing facility in Ringaskiddy. The multi-million euro investment almost doubles the capacity of Hovione’s spray drying facilities in Ireland and will create more than 20 new positions. Hovione said this latest investment reinforces the company's position as a global leader in spray drying for pharma applications.   This manufacturing technology, the company explained, is "especially important for inhalable therapies and oral medications with low bioavailability, enabling more effective treatments".  Deputising for the Mayor of the County of Cork, councillor Audrey Buckley said:  “I am delighted to welcome this very significant investment and the creation of further highly skilled jobs in Cork today.  “It reinforces Hovione’s commitment to the region and the innovative solutions it provides to the pharmaceutical industry in Ireland.” Meanwhile Michael McGrath, the European Commissioner-Designate for Democracy, Justice and the Rule of Law, welcomed the expected jobs boost the expansion is to create.  “This latest investment highlights the success of Hovione’s facility in Ringaskiddy, and underlines the continued resilience of Ireland’s pharmaceutical manufacturing sector.  “I am delighted that Hovione will be shortly welcoming new team members to this expanded facility, and I wish both them and Hovione every success”. Jean-Luc Herbeaux, Hovione's chief executive said: “This newly opened facility further strengthens Hovione's position as the global CDMO of choice for spray drying development and manufacturing services.  “It also underscores our commitment to bringing first-in-class technology and world-leading manufacturing services to Irish shores.  “Ireland provides a superior environment for pharmaceutical manufacturing, and we are delighted to be a part of it.” CEO of IDA Ireland, Michael Lohan, said Hovione "has made a significant contribution both locally and nationally through employment and investment alike". "We warmly welcome Hovione’s commitment to investing in Cork and we wish them continued success," he added.    Read the full article on EchoLive.ie    

Press Clipping

Pharma company announces expansion of Cork facility to create more than 20 new jobs

Nov 25, 2024

Pharmaceutical contract development and manufacturing company Hovione has officially commissioned an expansion at its manufacturing facility in Ringaskiddy, Cork.  Announcing the development on Monday, the multi-million euro investment almost doubles the capacity of Hovione’s spray drying facilities in Ireland and will create more than 20 new positions. This manufacturing technology is especially important for inhalable therapies and oral medications with low bioavailability, enabling more effective treatments, the company said. Deputising for the Mayor of the County of Cork, Cllr. Audrey Buckley said: “I am delighted to welcome this very significant investment and the creation of further highly skilled jobs in Cork today.  "It reinforces Hovione’s commitment to the region and the innovative solutions it provides to the pharmaceutical industry in Ireland.”  Michael McGrath, the European Commissioner-Designate for Democracy, Justice and the Rule of Law said: “This latest investment highlights the success of Hovione’s facility in Ringaskiddy, and underlines the continued resilience of Ireland’s pharmaceutical manufacturing sector. "I am delighted that Hovione will be shortly welcoming new team members to this expanded facility, and I wish both them and Hovione every success”. This latest investment builds on the momentum of the recently announced spray drying capacity expansion at the Company's East Windsor, New Jersey, site.  Jean-Luc Herbeaux, Hovione´s Chief Executive said: “This newly opened facility further strengthens Hovione´s position as the global CDMO of choice for spray drying development and manufacturing services.  "It also underscores our commitment to bringing first-in-class technology and world-leading manufacturing services to Irish shores. Ireland provides a superior environment for pharmaceutical manufacturing, and we are delighted to be a part of it.” IDA chief executive Michael Lohan said the company has made a significant contribution both locally and nationally, adding: "I am pleased to be here today to mark another step on that journey. We warmly welcome Hovione’s commitment to investing in Cork and we wish them continued success.”   Read the full article on IrishExaminer.com  

Press Clipping

Pharma company Hovione to double capacity at Cork site as part multi-million euro investment

Nov 25, 2024