Press Room

52nd Organic Process Research and Development (OPR&D)

Start
Monday, September 23, 2024
End
Wednesday, September 25, 2024
Location: Prague, Czech Republic
Hoviong is present at the OPR&D Conference in Prague. Contact us today and schedule a meeting | Hovione

Visit Hovione at OPR&D, the Leading Process Chemistry Conference from September 23-25 in Prague, Czech Republic. 

We are proud to be the Gold Sponsor of the conference, the place to be to learn about the latest scientific updates in the industry and to network with chemical experts from around the globe.
 

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Join the conference's sessions led by our experts

"Women in Process Chemistry"

Chair: Susana Lucas, Ph.D., Sr. Manager, R&D Process Chemistry Development

September 23 from 2:00 PM to 5:00 PM

We are honored to chair and sponsor the Women in Process Chemistry Session at the 52nd OPR&D Conference in Prague. Our expert Susana Lucas will be leading the conversation on innovative approaches to enhance process development efficiency alongside key opinion leaders in the field, including Samantha Staniland from AstraZeneca, Stephanie Kosnik from Boehringer Ingelheim, Dide Verhoeven from Symeres, and Gabriele Menges-Flanagan from Fraunhofer IMM.

Gain valuable insights into sustainable high-throughput experimentation (HTE) techniques in early-stage discovery and learn about cutting-edge crystallization methodologies to overcome isolation challenges. Additionally, learn about the synthesis and process development of an antiviral drug through a multi-kg case study, and delve into the world of organometallics in flow chemistry.

In line with our commitments around diversity, equity and inclusion, we are proud to be part of this initiative that encourages collaboration and innovation in process chemistry.
 

"Micellar Catalysis: Enabling Sustainable Chemistry in Water"

João Sardinha, Ph.D., Senior Scientist, R&D Process Chemistry Development

September 24 from 11:00 AM to 11:45 AM

Description: Micellar chemistry, often referred to as micellar catalysis, presents a greener alternative to traditional organic solvents. Although water can occasionally replace solvents effectively, its compatibility with organic reagents is not always ideal. Nevertheless, recent developments have led to the introduction of innovative additives, such as aqueous micelles that function as "nanoreactors". These nanospheres, formed by surfactant molecules create a unique environment that enables chemical transformations in aqueous media. This advancement represents a significant step forward in sustainable chemistry, reducing reliance on harmful solvents and promoting environmentally friendly practices in chemical synthesis.
At Hovione, we have been exploring the application of micellar chemistry in various types of reactions, namely amide bond formation, SNAr, Suzuki couplings, nitro reductions, Buchwald-Hartwig amination among others. Several examples and comparison with traditional organic solvent methods will be presented. Additionally, a comparative study of an alkylation reaction in the synthesis of a Hovione API will be showcased, highlighting the superior efficiency, safety, and environmental benefits of micellar chemistry over the existing organic solvent process. The micellar process was successfully developed and optimized by means of Design of Experiments (DoE) ensuring robust and effective conditions. Following successful scale-up, we are about to implement this process at the pilot plant scale.

 

Schedule your meeting today and find out how we can support your project.

Find more about OPR&D Conference

 

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Drug Substance at Hovione

Your partner in custom development and manufacturing of APIs.

Schedule a meeting with our experts to learn more about our custom development and manufacturing of APIs. With worldwide locations, an exemplary regulatory track record and a ‘can do’ approach, our experienced development and manufacturing teams will provide the competence, capacity, safety and quality you expect to manufacture your product on time, on budget and to the very highest standards.

Curious about how combining human expertise with advanced computational models can enhance green chemistry principles in sustainable process chemistry? 

Read our article, ‘Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics’ published in OPR&D Journal here.

 

 

 

 

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ViSync® Technologies, a joint venture between Hovione, a global specialist integrated CDMO and leader in spray drying and particle engineering, and iBET (Instituto de Biologia Experimental e Tecnológica), a not-for-profit R&D institution specializing in Biotechnology and Life Sciences, is proud to announce the appointment of Elsa Abranches as its Chief Scientific Officer (CSO). Headquartered in Oeiras, Portugal, ViSync® Technologies was established to address unmet technological needs in the pharmaceutical industry, focusing on developing innovative solutions for the cell and gene therapy space. By leveraging Hovione's expertise in pharmaceutical development, particle engineering, and industrialization, alongside iBET’s pioneering research in biotechnological sciences, ViSync® is uniquely equipped to drive innovation in targeted delivery and stabilization of next-generation therapies.  Dr. Elsa Abranches brings over two decades of experience in cell and gene therapy, with a strong track record of leading diverse teams in dynamic environments. In her new role as ViSync® CSO, she will drive the company’s R&D strategy and scientific vision, positioning ViSync® as a leader in innovation within the dynamic and rapidly advancing field of cell and gene therapy. “We are thrilled to welcome Elsa Abranches as Chief Scientific Officer of ViSync®,” said Dr. Christoph Bruecher, Chairman of the Board of ViSync® and VP Business Transformation at Hovione. “Her expertise and vision in the field of advanced therapeutics will be pivotal in driving ViSync’s mission to create transformative solutions that empower pharmaceutical companies and improve patient treatment outcomes.” Dr. Manuel Carrondo, Director of the Board of ViSync® and Vice President of iBET, added, “Elsa’s appointment underscores our commitment to establishing ViSync® as a leader in cell and gene therapy innovation. Her scientific leadership will be critical as we tackle some of the most pressing challenges in the field of new modalities drug delivery.” Elsa Abranches, new Chief Scientific Officer of ViSync®, said: “Having worked in different countries and industries, I’m thrilled to bring my experience back home to join ViSync®. This new venture represents an incredible opportunity to collaborate with local and international partners to drive innovation in advanced therapeutics and help shape the future of life-changing therapies”.     About Hovione Hovione is an international company with over 60 years of experience in pharmaceutical development and manufacturing operations. As a Contract Development and Manufacturing Organization (CDMO) it has a fully integrated offering of services for drug substances, drug product intermediates and drug products. The company has four FDA inspected sites in the USA, Portugal, Ireland and China and development laboratories in Lisbon, Portugal and New Jersey, USA. Hovione provides pharmaceutical customers services for the development and compliant manufacture of innovative drugs, including highly potent compounds, and customized product solutions across the entire drug life cycle. In the inhalation area, Hovione offers a complete range of services, from API, formulation development and manufacturing, capsule filling and devices. Hovione's culture is based on innovation, quality and dependability. Hovione is a member of Rx-360, EFCG and participates actively in industry quality improvement initiatives to lead new global industry standards.   About iBET iBET is a private non-profit institution devoted to biotechnology research, with 35 years of experience creating and transferring knowledge to the global biopharma and biotech sectors. iBET’s core expertise lies on the development of bioprocesses and analytical tools for Advanced Therapeutic Medicinal Products (ATMPs), including cell and gene therapies, vaccines, antibodies and other innovative therapeutic products. Leveraged by the emerging areas of Data Science and Translational Immunology, we offer bespoke R&D services from early-stage R&D to GMP manufacturing. iBET’s infrastructure comprises cutting-edge laboratories, a GMP certified Analytical Services Unit, and a Late-Stage R&D and Bioproduction Unit, covering upstream and downstream process development, bioanalytical tools for critical quality attribute monitoring, to scale-up and tech transfer. iBET also hosts satellite laboratories of major pharmaceutical companies and serves as an incubation platform for start-up/spin-off companies. iBET is driven by its innovative and agile culture of continuous improvement and a strong sense of ambition, ownership and commitment in developing and delivering the best solutions to our stakeholders.     

News

ViSync® Technologies appoints Elsa Abranches as Chief Scientific Officer

Dec 19, 2024

International pharmaceutical contract development and manufacturing organisation (CDMO) Hovione has today officially commissioned an expansion at its manufacturing facility in Ringaskiddy. The multi-million euro investment almost doubles the capacity of Hovione’s spray drying facilities in Ireland and will create more than 20 new positions. Hovione said this latest investment reinforces the company's position as a global leader in spray drying for pharma applications.   This manufacturing technology, the company explained, is "especially important for inhalable therapies and oral medications with low bioavailability, enabling more effective treatments".  Deputising for the Mayor of the County of Cork, councillor Audrey Buckley said:  “I am delighted to welcome this very significant investment and the creation of further highly skilled jobs in Cork today.  “It reinforces Hovione’s commitment to the region and the innovative solutions it provides to the pharmaceutical industry in Ireland.” Meanwhile Michael McGrath, the European Commissioner-Designate for Democracy, Justice and the Rule of Law, welcomed the expected jobs boost the expansion is to create.  “This latest investment highlights the success of Hovione’s facility in Ringaskiddy, and underlines the continued resilience of Ireland’s pharmaceutical manufacturing sector.  “I am delighted that Hovione will be shortly welcoming new team members to this expanded facility, and I wish both them and Hovione every success”. Jean-Luc Herbeaux, Hovione's chief executive said: “This newly opened facility further strengthens Hovione's position as the global CDMO of choice for spray drying development and manufacturing services.  “It also underscores our commitment to bringing first-in-class technology and world-leading manufacturing services to Irish shores.  “Ireland provides a superior environment for pharmaceutical manufacturing, and we are delighted to be a part of it.” CEO of IDA Ireland, Michael Lohan, said Hovione "has made a significant contribution both locally and nationally through employment and investment alike". "We warmly welcome Hovione’s commitment to investing in Cork and we wish them continued success," he added.    Read the full article on EchoLive.ie    

Press Clipping

Pharma company announces expansion of Cork facility to create more than 20 new jobs

Nov 25, 2024

Pharmaceutical contract development and manufacturing company Hovione has officially commissioned an expansion at its manufacturing facility in Ringaskiddy, Cork.  Announcing the development on Monday, the multi-million euro investment almost doubles the capacity of Hovione’s spray drying facilities in Ireland and will create more than 20 new positions. This manufacturing technology is especially important for inhalable therapies and oral medications with low bioavailability, enabling more effective treatments, the company said. Deputising for the Mayor of the County of Cork, Cllr. Audrey Buckley said: “I am delighted to welcome this very significant investment and the creation of further highly skilled jobs in Cork today.  "It reinforces Hovione’s commitment to the region and the innovative solutions it provides to the pharmaceutical industry in Ireland.”  Michael McGrath, the European Commissioner-Designate for Democracy, Justice and the Rule of Law said: “This latest investment highlights the success of Hovione’s facility in Ringaskiddy, and underlines the continued resilience of Ireland’s pharmaceutical manufacturing sector. "I am delighted that Hovione will be shortly welcoming new team members to this expanded facility, and I wish both them and Hovione every success”. This latest investment builds on the momentum of the recently announced spray drying capacity expansion at the Company's East Windsor, New Jersey, site.  Jean-Luc Herbeaux, Hovione´s Chief Executive said: “This newly opened facility further strengthens Hovione´s position as the global CDMO of choice for spray drying development and manufacturing services.  "It also underscores our commitment to bringing first-in-class technology and world-leading manufacturing services to Irish shores. Ireland provides a superior environment for pharmaceutical manufacturing, and we are delighted to be a part of it.” IDA chief executive Michael Lohan said the company has made a significant contribution both locally and nationally, adding: "I am pleased to be here today to mark another step on that journey. We warmly welcome Hovione’s commitment to investing in Cork and we wish them continued success.”   Read the full article on IrishExaminer.com  

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Pharma company Hovione to double capacity at Cork site as part multi-million euro investment

Nov 25, 2024