Press Room

2023 AIChE Annual meeting

Start
Sunday, November 05, 2023 - 09:00
End
Friday, November 10, 2023 - 17:00
Location: Orlando, United States
AIChE 2023 Annual Meeting | Hovione

Meet Hovione team at the 2023 AIChE Annual Meeting and find their exciting presentations and Hovione’s latest research and innovations. The AIChE Annual Meeting is an educational forum covering a wide range of topics relevant to cutting-edge research, new technologies, and emerging growth areas in chemical engineering. We look forward to meeting academic and industry experts and exchanging knowledge.

 

Date: November 5, 2023

Oral Presentation 547b

Title: PAT Development Strategy in the Feed Frame As an Enabler for Faster Continuous Manufacturing Implementation
Presenting Author: Pedro Durão (Senior Scientist II, Modelling & PAT)

3:51 PM - 4:12 PM
Celebration 7 (Convention Level)

Oral Presentation 653f

Title: Modeling Continuous Film Coating Process in Consigma Coater: What Changes?
Presenting Author: Pedro Monteiro (Scientist, Formulation Development)

5:15 PM - 5:36 PM
Celebration 8 (Convention Level)

Oral Presentation 653g

Title: Model-Based Application for a Safe Scale-up and Equipment Selection on a Pressure Generating Pharmaceutical Process
Presenting Author: Frederico Montes (Scientist, Corporate Technical Services)

5:36 PM - 5:57 PM
Celebration 8 (Convention Level)

 

Date: November 6, 2023

Session 113 - Particle Characterization

Chair: Sarang Oka, Continuous Manufacturing Development Engineer

12:30 PM - 3:00 PM
Bayhill 19 (Lobby Level)

Poster Presentation 198d

Title: Development and Application of Residence Time Distribution (RTD) Models for a Continuous Direct Compression Process
Presenting Author: José Granjo (Modelling & PAT Scientist)

3:30 PM - 5:00 PM
Regency Ballroom R/S (Convention Level) 

Poster Presentation 198v

Title: Cryo Jet Milling for Micronization Enhancement of Inhalation Particles
Presenting Author: Inês Gomes (IST), with João Pires, Filipe Vultos, Ricardo Velez (Scientists, Hovione) and Ana Azevedo (IST)

3:30 PM - 5:00 PM
Regency Ballroom R/S (Convention Level)

Poster Presentation 643g

Title: A Template for Investigating NIR Spectroscopy-Based Deviations
Presenting Author: Ankita Naik (Modelling & PAT Scientist, CM Process Development)

5:36 PM - 5:57 PM
Celebration 8 (Convention Level)

 

Date: November 7, 2023

Oral Presentation 500g

Title: Recent Advances in ASD Formulations: Combining Dispersome® Technology with a High-Throughput Screening Setup
Presenting Author: Inês Ramos (Senior Scientist, Formulation Development)

1:08 PM - 1:26 PM
Manatee Spring II (Lobby Level)

Oral Presentation 500h

Title: Amorphous Solid Dispersions By Spray Drying: From Early Formulation to Commercial Lifecycle Management
Presenting Author: José Luís Santos, Director, Technology Intensification

1:26 PM - 1:44 PM
Manatee Spring II (Lobby Level)

Oral Presentation 583a 

Title: Impact of Rheology and Process Variables on the Development and Scale-up of a Drum Filling Process for Dry Powder Inhalers
Presenting Author: Rui Churro (Senior Scientist, Process Development)

3:30 PM - 3:51 PM
Celebration 8 (Convention Level)

Oral Presentation 583d

Title: Droplet to Particle model prediction by coupling solution rheological characterization, CFD and Phase doppler analysis
Presenting Author: Márcia Tavares (Scientist, Process Development)

4:33 PM - 4:54 PM
Celebration 8 (Convention Level)

 

Date: November 8, 2023

Oral Presentation 74c

Title: Bridging Crystallization and Mechanical Properties to Particle Size Reduction Efficiency in Jet Milling Industrial Pharmaceutical Processes
Presenting Author: Gonçalo Marcelo (Scientist, Particle Engineering)

9:00 AM - 9:20 AM
Bayhill 19 (Lobby Level) 

Poster Presentation 303r

Title: Integrating Three-Fluid Nozzle Technology as a QbD Tool for Enhancing Advanced Respiratory Drug Delivery Formulations: A Statistical Modeling Approach 
Presenting Author: Rui Churro (Senior Scientist, Process Development)

3:30 PM - 5:00 PM
Regency Ballroom R/S (Convention Level)

Poster Presentation 84at

Title: Asset Intensification: Application of Modelling Tools and Methodologies from a CDMO Perspective
Presenting Author: Filipe Ataide (Senior Scientist, Technology Intensification)

3:30 PM - 5:00 PM
Regency Ballroom R/S (Convention Level)

 

 

Date: November 9, 2023

Oral Presentation 355e

Title: Controlled Crystallization through Microfluidization As an Alternative Particle Engineering Technology for Inhalation Products
Presenting Author: Gonçalo Marcelo (Scientist, Particle Engineering)

9:24 AM - 9:45 AM
Celebration 8 (Convention Level)

Oral Presentation 649e

Title: Use of Statistical Process Control to Drive Process Improvements in Continuous Manufacturing
Presenting Author: Ankita Naik (Modelling & PAT Scientist, CM Process Development)

4:58 PM - 5:20 PM
Celebration 8 (Convention Level)

 

 

 

schedule a meeting

 

 

 

Schedule your meeting today 

 

 

Also in the Press Room

See All

Continuous Tableting (CT) is defined as continuous manufacturing of oral dose drugs, specifically tablets. As per ICH's Q13 definition1, a continuous manufacturing process in the pharmaceutical industry comprises at least two unit operations integrated from a mechanical and software perspective. There is a wide combination of possible CT process configurations that are dependent on the needs of the intended product formulation and each of the individual unit operations that constitute the process train can be continuous, semi-continuous, or batch processes. The typical manufacturing processes for tablet formulation are direct compression (DC), dry granulation (DG) and wet granulation (WG)2 - details on these manufacturing processes are beyond the scope of this article, so the interested reader is directed to relevant literature. The actual implementation of CT technology in a facility can broadly vary depending on the level of desired integration and automation. Process trains can be designed to be flexible and converted between multiple configurations (e.g. continuous DC, DG and WG), controlled by the end user from one single software and within a single clean room. The other possibility would be for subsections of the CT process to be divided into multiple clean rooms where inprocess materials are transferred between suites via a bin-to-bin approach (e.g. a granulation suite to prepare granules from raw materials followed by continuous DC (CDC) to blend the granules and produce tablets). The level of automation and instrumentation designed into the CT process (typically involving Process Analytical Technologies, PAT) can open the possibility to implement sophisticated control strategies. Key components of a control strategy that need to be considered for CT are material tracking and genealogy, knowledge of the residence time distribution (RTD), and in-process controls (spectroscopic and/or soft sensors based on process parameters). Holistically, these control strategy elements enable the implementation of a material diversion strategy to automatically divert out of specification material from the process. In their most advanced form, control strategies may also enable real time release testing (RTRt) of the final tablet drug product and reduce the off-line analytical burden and the number of operators needed to manage the process.   Read the full article at gmp-journal.com  

Article

Continuous Tableting and the Road to Global Adoption

Mar 04, 2024