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Article / Apr 28, 2023

Capsule filling for DPIs - Linking Process scales through advanced characterisation and Quality by Design

ONDrugDelivery, 28 April 2023

Capsule filling for DPIs | Hovione

In this article, Rui Churro, PhD, Senior Scientist, Carolina Lopes, Associate Scientist, and João Pires, PhD, R&D Manager, all of Hovione’s Inhalation and Advanced Drug Delivery group, discuss the value of rheological characterisation of powders to expedite and de-risk the scale-up of DPI capsule-filling processes.

Composite particles are gaining traction as an alternative formulation strategy for dry powder inhalers. Typically, these engineered particles present low densities and small aerodynamic particle size, promoting an effective delivery to the lung. However, these unique properties can also raise operational challenges, such as poor flowability and powder agglomeration, during downstream filling processes. Since dry powder inhalers may contain doses as low as few milligrams, it is essential to understand the rheologic properties of the filled powders and select the best filling technology/conditions towards reaching the required filling accuracy.

Hovione has been deeply investing in developing formulation/process development strategies together with... Read more

 

 

 

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Three is the magic number for Hovione as it’s once again been certified as a top employer. For the third consecutive year, all four of its manufacturing sites - Lisbon, Cork, East Windsor in USA, and Macau - have been certified as Top Employers by the Top Employers Institute. Hovione is an international integrated pharmaceutical development and manufacturing organisation. This certification follows, Hovione said, a rigorous audit process. Jean-Luc Herbeaux, Chief Executive Officer, Hovione, explained: “This recognition reflects the exceptional dedication and collaboration of the entire Hovione team. Hovione is a development and manufacturing service company operating in one of the most demanding and regulated industries. We understand that our success is deeply rooted in our people. “Together, as One Hovione, we are committed to continuously refining our practices to foster a workplace that inspires motivation and enhances employee satisfaction, so that, every day, our team members bring their best selves to work, driving innovation and excellence at every step,” Jean-Luc added. Ilda Ventura, Senior Vice-President of Human Resources and Member of the Management Board, Hovione, said: “This distinction underscores our unwavering commitment to our people. At Hovione, we design our HR systems and processes to ensure that every team member enjoys a consistent and fulfilling experience, regardless of their role, function, or location.” Imelda Cummins, HR Director for Hovione Ireland, said: “This distinguished accreditation is a testament to our commitment to establish frameworks to attract, engage and retain top talent. We believe that our people are our greatest asset, and this recognition reflects the hard work and dedication of our entire team who strive every day to foster a culture of excellence, innovation, and collaboration. Receiving the Top Employer accreditation is motivation for us to keep pushing the boundaries of what it means to be an exceptional employer.” Hovione recently celebrated the opening of a multi-million euro expansion at its site in Ringaskiddy, which almost doubled the capacity of its spray drying facilities.   Read the full article on CorkIndependent.com  

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